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CORD:USE is directed by leading doctors in cord blood transplantation. Public donations collected by CORD:USE are sent to the Carolinas Cord Blood Bank, a FACT-accredited laboratory under the direction of Dr. Joanne Kurtzberg.
There are so many things to think about when you have a child. One of them is the blood from your baby’s umbilical cord (which connects the baby to the mother while in the womb). It used to be thrown away at birth, but now, many parents store the blood for the future health of their child. Should you do it?
Your baby isn’t the only one who may benefit from having access to preserved newborn stem cells. The cells can potentially be used by siblings and parents, too. In many cord blood treatments, stem cells from a matched family member are preferred.
Stem cell transplants from a related family member are less likely to be rejected, therefore having your baby’s stem cells available makes it less likely you would have to search for an unrelated donor who is a match
Mother’s Day is just around the corner and we are celebrating by sharing one of our employee’s journey as a new mom. Tiffany shares 5 things she’s learned being a new parent to a 6 month old. Can you relate?
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There is now compelling evidence that MSCs, guided by chemokines and other cues emanating from areas of pathology such as tumors, will “home” specifically to those areas. The supporting connective tissue stroma of a tumor is formed in a manner similar to wound healing and scar formation (64), and tumors generate signals to recruit stromal cells from contiguous regions as well as from bone marrow to sustain themselves (65,66). Because UCM stem cells are very closely related to MSCs (28), it would not be surprising to find that they also will home to tumors, and in fact such a phenomenon has been observed in preliminary experiments in our laboratory (unpublished observations). The exact signals that recruit transplanted or endogenous cells to regions of inflammation or neoplasia remain obscure. However, stromal cell-derived factor-1α plays a crucial role in recruitment of bone marrow-derived cells to the heart after myocardial infarction (67). Matrigel invasion assays have implicated such molecules as platelet-derived growth factor-BB, epidermal growth factor, and stromal cell-derived factor-1α as chemokines for MSCs; however, neither basic FGF (bFGF) nor vascular endothelial growth factor (VEGF) had an affect (68). In any event, the directed trafficking of umbilical and other mesenchymal stem cells to tumors opens the enticing prospect that they may be a platform for targeted delivery of high local levels of protein. Often, such proteins have a short half-life and/or cause major side effects when given systematically.
The blood that remains in the umbilical cord and the placenta after birth is called “cord blood”. Umbilical cord blood, umbilical cord tissue, and the placenta are all very rich sources of newborn stem cells. The stem cells in the after birth are not embryonic. Most of the stem cells in cord blood are blood-forming or hematopoietic stem cells. Most of the stem cells in cord tissue and the placenta are mesenchymal stem cells.
Complicating matters further, each public bank has its own registry, so transplant centers must search many different databases to find a match for a patient. Currently, a Caucasian patient has an 88 percent chance of finding a cord-blood match through a public-bank registry, and minorities have a 58 percent chance. (Collection hospitals tend to be in areas with higher rates of Caucasian births, and parents from certain ethnic groups are wary of donating for religious or cultural reasons.)
Umbilical cord blood was once discarded as waste material but is now known to be a useful source of blood stem cells. Cord blood has been used to treat children with certain blood diseases since 1989 and research on using it to treat adults is making progress. So what are the current challenges for cord blood research and how may it be used – now and in the future?
Phone 1-888-932-6568 to connect with a CBR Cord Blood Education Specialist or submit an online request. International callers should phone 650-635-1420 to connect with a CBR Cord Blood Education Specialist.
With Cryo-Cell International, you get exceptional service and the best price possible, with no unexpected fees. We offer a number of special discounts in addition to in-house financing options to keep the cost of cord blood banking in everyone’s reach. We will also meet the price of any reputable competitor through our best-price guarantee.
LifebankUSA seeks mothers in NEW YORK & NEW JERSEY ONLY who will donate both their cord blood and their placenta. The donations support an international registry, clinical trials and research. Donations can be taken from any hospital, but mothers must register at least 8 weeks prior to delivery and pass a health screening.
A literature review revealed a question about the stability of umbilical cord cells in culture. Two groups found that the cell surface marker expression shifted over passage (28,29). Sarugaser’s (29) work indicated that HLA-1 was lost as a result of cryopreservation. Whereas, umbilical cord perivascular cells lost cell surface staining for HLA-1 with freeze–thaw, HLA-1 surface staining was consistent out to passage 5 for cells maintained in culture. In contrast, Weiss et al. (28) reported a decrease in the percentage of cells expressing CD49e and CD105 when human UCM cells were maintained in culture for passage 4–8 and no significant changes in HLA-1 expression. This question about the stability of surface marker expression may indicate that epigenetic phenomena associated with cell culture are influencing the cord MSC-like cells. Further characterization of the cord MSC-like cells is needed to understand the mechanisms of these changes.
The majority of programs that accept cord blood donations require the mother to sign up in advance. In the united States, the current requirement is to sign up by the 34th week of pregnancy. This cannot be over-stressed; time and time again, mothers who want to donate are turned away because they did not inquire about donation until it was too late.
^ a b c d e f Juric, MK; et al. (9 November 2016). “Milestones of Hematopoietic Stem Cell Transplantation – From First Human Studies to Current Developments”. Frontiers in Immunology. 7: 470. doi:10.3389/fimmu.2016.00470. PMC 5101209 . PMID 27881982.
While banking cord blood is a new experience for many parents, it is a simple one. After all, most mothers are worried about how the delivery will go and don’t want to also be worried about the details of collecting, processing and cryo-preserving their babies’s cord blood. Thankfully, the healthcare provider and the cord blood bank do most of the work. Here are the steps found in cord blood banking:
^ Jump up to: a b c American Academy of Pediatrics Section on Hematology/Oncology; American Academy of Pediatrics Section on Allergy/Immunology; Lubin, BH; Shearer, WT (January 2007). “Cord blood banking for potential future transplantation”. Pediatrics. 119 (1): 165–70. doi:10.1542/peds.2006-2901. PMID 17200285.
While the stem cell count is smaller during a cord blood transplant, these cells multiply quickly, and researchers are studying new methods to increase cells naturally. Compared to bone marrow, cord blood cells multiply faster and don’t require an exact match type to complete a successful transplant. Some techniques medical experts are testing to increase the amount of stem cells include:
There are several cord blood banks that are accredited by the American Association of Blood Banks. Most offer information on cord blood banking and provide private cord blood banking services. With a little research, you should be able to locate a credible cord blood bank online.
Our work has focused on human umbilical cord matrix (UCM) cells. There are cells isolated in large numbers from the Wharton’s jelly of human cords (25–28). Two other research labs have published on the isolation and characterization of cells from the Wharton’s jelly: Dr. Davies’ lab at the University of Toronto (29) and Dr. Y. S. Fu at the National Yang-Ming University, Taipei (30–32). All three groups reported that UCM cells are MSC-like cells and are robust. These cells can be isolated easily, frozen/thawed, clonally expanded, engineered to express exogenous proteins, and extensively expanded in culture. Human UCM cells express a marker of neural precursors, nestin, without exposure to differentiation signals (26,28,30). In response to differentiation signals, human UCM cells can differentiate to catecholaminergic neurons, expressing tyrosine hydroxylase TH (28,30,31). Human UCM cells meet the basic criteria established for MSCs described previously (29,32). Similarly, MSC-like cells are derived from other umbilical cord tissues, e.g., umbilical vein sub-endothelium, umbilical cord blood, amnion, placenta, and amniotic fluid (Table 1).
“Raising a family is expensive enough,” says Jeffrey Ecker, MD, director of obstetrical clinical research at Massachusetts General Hospital, in Boston, and a member of ACOG’s ethics committee. “There’s no reason for parents to take on this additional financial burden when there’s little chance of a child ever using his own cord blood.”
There are also hundreds of human clinical trials being performed using cord blood to treat conditions and diseases that affect millions of people in the U.S. alone. These trials involve regenerative medicine and other applications for the treatment of Diabetes, Cerebral Palsy, Autism, Strokes, Neonatal & Pediatric Brain Injury, Alzheimer’s & Spinal Cord Injury to name a few (see www.clinicaltrials.gov). The existence of clinical trials does not guarantee that cord blood will be successful in the treatment of those diseases in the future. While you can’t plan on health issues your child may face, you can have possible treatment options.
And as Victor and Tracey Dones learned, a child’s own cord blood can’t always be used to treat him, even when he’s young. “Childhood leukemia is one of the diseases private banks like to play up, but most kids with leukemia are cured with chemotherapy alone. If a transplant is needed, we wouldn’t use a child’s tainted cord blood,” Dr. Kurtzberg says.
Congratulations to the Marepalli family, this week’s winners of a free year of storage! CBR Clients: Enter for a chance to win by tagging a family photo with #CBRFamilyContest! #MyStemCellsLiveAtCBR pic.twitter.com/RLIx54bLqS
Florida Hospital for Children is conducting an FDA-regulated phase I clinical trial to investigate the use of a child’s stem cells derived from their own cord blood as a treatment for acquired sensorineural hearing loss.
Along with cord blood, Wharton’s jelly and the cord lining have been explored as sources for mesenchymal stem cells (MSC), and as of 2015 had been studied in vitro, in animal models, and in early stage clinical trials for cardiovascular diseases, as well as neurological deficits, liver diseases, immune system diseases, diabetes, lung injury, kidney injury, and leukemia.
Most of the diseases on the proven treatment list are inherited genetic diseases. Typically, these treatments require a donor transplant, as from a sibling. In fact, research shows that treatments using cord blood from a family member are about twice as successful as treatments using cord blood from a non-relative.9a, 17 To date, over 400 ViaCord families have used their cord blood 56% were for transplant.1
Fill out medical history sheets. The bank will ask you and your doctor to fill out medical forms that cover your infant, adolescent, and adult health. This helps the bank understand your general medical health to see if your child’s cord blood is useable in treatment. Overall, public banks usually accept healthy mothers without a history of severe inherited conditions.